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-synuclein, and that is a key ingredient of Lewy bodies, in PARK one in 1997 and parkin in PARK 2 in 1998, which can be an E3 ubiquitin ligase and results in endoplasmic reticulum (ER) stress, suggest that dysfunction on the intracellular proteinase methods, including ubiquitin-proteasome method or lysosomal program, which gets rid of needless harm
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